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Different Types of Magnesium and How to Take Them - In Perimenopause

Magnesium is a game-changer for perimenopause and menopause. We dive into glycinate, threonate, and more—exploring their effects, benefits, and how to take them for our needs.

Radiant Creative

May 9, 2025

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We perimenopausal and menopausal women are navigating a wild ride—hormones singing like an emo 90s mixtape, leaving us with mood swings, sleep issues, and muscle tension. As a bit of a health nerd—I’m the type who stays up all night listening to science podcasts—I’ve found magnesium to be a game-changer for us. When I discovered its benefits during my luteal phase, I had to dig deeper. Turns out, not all magnesium is created equal, and how we take it matters. Let’s break down the science of magnesium types, their effects, and how they support our unique needs, plus practical ways to make them part of our self-care routine.


Types of Magnesium: Which One’s Your Vibe?


Magnesium comes in different forms, each with distinct properties tailored to our perimenopausal challenges, and each with its own perks. Magnesium glycinate is my go-to—it’s highly bioavailable, meaning our bodies absorb it efficiently, and research shows it supports relaxation and sleep quality, crucial when night sweats keep us up. A 2017 study found glycinate reduces anxiety by calming the nervous system, a win for our mood swings. 


Magnesium threonate, which my favorite neuroscientist Dr. Andrew Huberman loves to talk about, is another standout, known for crossing the blood-brain barrier. A 2010 study on older adults showed it enhances cognitive function and memory—perfect for tackling the brain fog we often face in menopause.


Magnesium oxide, commonly found in supplements, is less absorbable; a 2001 study noted its bioavailability is only about 4%, making it less effective for our needs despite being cheaper.kind of like dial-up internet in the 90s, it works, but there’s better out there.


How Magnesium Supports Perimenopause and Menopause


Science shows magnesium addresses key symptoms we face. It regulates cortisol, reducing stress-related anxiety, which is vital when hormonal fluctuations leave us on edge. It also supports muscle relaxation, easing cramps and tension that can worsen with declining estrogen. For brain health, threonate’s cognitive benefits help us stay sharp, while glycinate’s calming effects improve sleep—critical since up to 60% of menopausal women report insomnia, per a 2018 study.


Ways to Take Magnesium for Our Needs


We can take magnesium in ways that fit our lifestyles. I mix a magnesium glycinate powder blend called Moon Brew into heavy cream with a pinch of turmeric for a nighttime ritual that beats any 90s rom-com—it helps us get deep, restorative sleep. Dermal options, like VAL Magnesium Cream, which uses magnesium chloride, work wonders for sore muscles; it’s light, absorbs beautifully, and smells wonderful, making it a favorite for post-workout relief. Another option—soaking in Epsom salts for 20 minutes—feels like a warm hug. Mix it with essential oils and a candle, and you don’t need to call “Calgon, Take Me Away!” like your mama did!


Magnesium is a must-have for us heroes in perimenopause and menopause. It ties into our luteal phase routine for PMS relief and beyond. What’s your magnesium method? Step into the spotlight and share your story in the comments!


Step into the spotlight and Share Your Story in the Comments!

Step Into the Spotlight:
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Behind the Scenes:
The Science Behind Our Perimenopause Hacks

  • Boyle, N. B., Lawton, C., & Dye, L. (2017). The effects of magnesium supplementation on subjective anxiety and stress—A systematic review. Nutrients, 9(5), 429. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/. 

    • Accessibility: Open-access article available via PubMed Central

  • Liu, G., Weinger, J. G., Lu, Z. L., Xue, F., & Sadeghpour, S. (2010). Efficacy and safety of MMFS-01, a synapse density enhancer, for treating cognitive impairment in older adults: A randomized, double-blind, placebo-controlled trial. Journal of Alzheimer’s Disease, 49(4), 971–990. https://pubmed.ncbi.nlm.nih.gov/26519439/

    • Accessibility: Abstract available on PubMed; full text requires journal subscription.

  • Firoz, M., & Graber, M. (2001). Bioavailability of US commercial magnesium preparations. Magnesium Research, 14(4), 257–262. https://pubmed.ncbi.nlm.nih.gov/11804306/. 

    • Accessibility: Abstract available on PubMed; full text requires journal subscription.

  • Baker, F. C., de Zambotti, M., Colrain, I. M., & Bei, B. (2018). Sleep problems during the menopausal transition: Prevalence, impact, and management challenges. Nature and Science of Sleep, 10, 73–95. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810528/. 

    • Accessibility: Open-access article available via PubMed Central.

  • Engen, D. J., et al. (2015). Effects of transdermal magnesium…. Journal of Integrative Medicine

    • Accessibility: Abstract available on PubMed; full text requires journal subscription.

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